Abstract PD-040

PW02-040 - Low-penetrance NLRP3 variants

Methods This multi-center observational study included 44 patients (25 children and 19 adults). All patients were symptomatic with some symptoms suggesting possible CAPS at the time of baseline examination. Genetic analysis detected one of the following NLRP3 variants: Q703K (n=18), R488K (n=6), and V198M (n=20). Clinical phenotypes were described and laboratory markers were analyzed. In order ...

PW01-040 – Definition of polymorphism C3435T MDR1 gene in JIA

Introduction Juvenile idiopathic arthritis (JIA) is one of the most common rheumatic disease in children. Brug of choice is methotrexate (MTX) cytostatic drug from the group of antimetabolites, folic acid antagonists. According to various authors, about 70% of patients receiving therapy with MTX are in remission for the disease. In 1988, MTX was approved FDA (Food and Drug Administration, USA) ...

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ABSTRACT

Abstract

Abstract